Tilorone: A Broad-Spectrum Antiviral For Emerging Viruses.
Identifieur interne : 000041 ( Main/Exploration ); précédent : 000040; suivant : 000042Tilorone: A Broad-Spectrum Antiviral For Emerging Viruses.
Auteurs : Sean Ekins [Oman] ; Peter B. Madrid [États-Unis]Source :
- Antimicrobial agents and chemotherapy [ 1098-6596 ] ; 2020.
Abstract
Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum antiviral in several countries of the Russian Federation. We have recently described activity in vitro and in vivo against the Ebola Virus. After a broad screening of additional viruses, we now describe in vitro activity against Chikungunya virus (CHIK) and Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV).
DOI: 10.1128/AAC.00440-20
PubMed: 32205350
Affiliations:
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